ICAM1 and Peritoneal Fibrosis: Studies have delayed that in the Surgery-induced peritoneal fibrosis in male Sprague-Dawley rats, BH reduces the expression levels of IL-1β, IL-6, TGF-β, TNF-α, ICAM-1, p-JNK and p-NF-κB, prevents adhesions after abdominal surgery, and reduces inflammation and prevents peritoneal fibrosis through inhibiting TAK1/JNK and TAK1/NF-κB signaling (Zhang Y. et al., 2014).