TNF and hydrops fetalis: In the CCL4-induced HF model in Balb/c mice, different doses of BBR (9 and 50 mg/kg) were treated for 2 weeks that ameliorated the increase in plasma enzyme activities and oxidative stress, decreased tumor necrosis factor-α (TNF-α), α-SMA, transforming growth factor beta 1 (TGF-β1) and MMP-9 expression, the levels of MMP-2 is increased, and induced the Cu/Zn SOD activity to be normalization (Domitrovic et al., 2013b).