Besides, studies have shown that BBR treatment can decreased LC3B and FTH1 expression, enhanced Ptgs2 and ROS levels, promoted ferritin hydrolysis, and increased iron overload in HSCs, suggesting that BBR enhances HSCs ferroptosis through inhibition of autophagy, which is beneficial to HF (Yi et al., 2021). Here, PTGS2 is linked to hydrops fetalis.