In addition, BBR inhibited the proliferation of HSCs in a dose-dependent manner and its IC50 value is 66.86 mM, but combination with sorafenib (10 μM) reduced it to 15.61 μM; molecular docking experiments further demonstrated that BBR binds to PEBP1 (can trigger ferroptosis), with a maximum binding energy of −8.51 kcal/mol; so BBR can promote HSC ferroptosis to alleviate HF through binding to PEBP1 (Xie et al., 2023). This evidence concerns the gene PEBP1 and hydrops fetalis.