In multivariable analyses adjusting for potential confounders, non-Hispanic Black participants with UC had less depressive and anxious symptomology than non-Hispanic White participants (PHQ-9 [depression] score: 5.88 [SE: 0.53] vs. 7.16 [SE: 0.19]; P = 0.038; GAD-7 [anxiety] score: 4.25 [SE: 0.42] vs. 5.25 [SE: 0.15]; P = .044) (Figure 4A, Supplementary Table 3). This evidence concerns the gene GAD1 and depressive disorder.