In addition, GLP-1R can be continuously activated to activate cAMP and P38 (94) and inhibit the conduction of the AKT and ERK1/2 signaling pathways (14, 16), ultimately inhibiting the proliferation of transplanted tumors in vivo and inducing the apoptosis of human pancreatic cancer cells in vitro (14). Here, GLP1R is linked to pancreatic neoplasm.