The other conditions include heart failure, cerebrovascular disease and diabetes mellitus due to type 4 renal tubular acidosis. Drugs and medications frequently causing hyperkalaemia include potassium-sparing diuretics, angiotensin-converting enzyme (ACE) inhibitors, non-steroidal anti-inflammatory drugs (NSAIDs) and angiotensin receptor blockers (ARBs). The gene discussed is ACE; the disease is heart failure.