By contrast, there were strong negative correlations of E-cadherin with vimentin in all tumor regions (Pearson r =−0.81, r= −0.81 to −0.89; p < 0.001, p < 0.001), confirming its essential role as a key epithelial marker and concomitant downregulation during dysfunctioning EMT efforts. This evidence concerns the gene VIM and neoplasm.