SD, standard deviation; PHC, primary healthcare; GIM, general internal medicine; CAD, coronary artery disease; CHF, congestive heart failure; eGFR, estimated glomerular filtration rate; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; RAAS, renin-angiotensin-aldosterone system; A1c, glycated hemoglobin; DM, diabetes mellitus. The gene discussed is REN; the disease is coronary artery disorder.