GBM, glioblastoma; IDH, Isocitrate Dehydrogenase; EGFR, epidermal growth factor receptor; MGMT, O6-methylguanine-DNA methyltransferase; ATRX, Alpha thalassemia/mental retardation syndrome X-linked; PFS, progression-free survival; OS, overall survival. The gene discussed is ATRX; the disease is Alpha-thalassemia.