For this purpose, we analyzed mutations in CDC25B and hub genes (CCNB1, BUB1B, BIRC5, KIF23, DLGAP5, CDK1, KIF11, NCAPG, KIF2C, and CDCA8) in HCC samples at the cBioPortal database (Figure 6(a)). This evidence concerns the gene BUB1B and hepatocellular carcinoma.