It has been reported that the Toll-like receptor signaling pathway not only plays an active role in suppressing immune surveillance of tumors but also alters the TME by promoting inflammatory responses and facilitating immune cell infiltration as well as tumor angiogenesis [29, 30].The possibility that the upregulation of immune checkpoints may be one of the mechanisms leading to the evasion of HCC cells from the immune system, these factors further explain the poorer prognosis of patients with high CDC25B expression. This evidence concerns the gene CDC25B and hepatocellular carcinoma.