Additionally, Chien et al. found that METTL3 in endothelial cells mediated inflammatory responses under pro-atherosclerotic flow treatment, including secretion of inflammatory cytokines, activation of the NF-κB signaling pathway, and adhesion of monocytes to endothelial cells, exacerbating the development of atherosclerosis (19). This evidence concerns the gene NFKB1 and atherosclerosis.