In CKD, studies have shown that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), CRP, TNF-α, and IL-6 are positively correlated and change in the same direction, reflecting the degree of inflammation in the body and the renal function status during the disease process, and are associated with poor prognosis. This evidence concerns the gene TNF and chronic kidney disease.