Group 2 (green) has 56 keywords, including tnf-alpha, C-reactive protein, mortality, pathogenesis, stage renal disease, obesity, smooth muscle cells, all cause, malnutrition, diabetes, association, cytokines, insulin resistance, atherosclerosis, vascular calibration, plasma, serum, protein, uremia, calcium, association, mortality, diabetes, malnutrition. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.