CHEK2 and cancer: Compared to controls, age-dependent penetrance in All CHEK2 variants for all cancers was significantly different in both MyCode (adjusted HR: 1.26 [95%CI 1.17-1.36], P-value: 6.1×10−10) and UKBB (adjusted HR 1.31 [95%CI 1.24-1.40], P-value: 2.0×10−16) (Figures 3A and 4A).