Genomic ascertainment of DICER1-associated thyroid disease (e.g., goiter) also found significant differences in DICER1 heterozygotes (vs. controls) in MyCode but not UK Biobank and may reflect the different medical cultures in the US and UK in approaches to medical imaging of the thyroid.30 Conversely, there was a significant excess risk of “malignant neoplasms of ill-defined, secondary and unspecified sites” (C76-C79) in UK Biobank but not MyCode. This evidence concerns the gene DICER1 and goiter.