19 The ACOT gene family encodes Acyl-CoA thioesterases, which hydrolyze coenzyme A esters into free fatty acids and coenzyme A. Prior work studying the metabolic differences of peripheral blood sera between 32 PV patients and 20 healthy controls suggests that derangements to fatty acid metabolism may provide a proliferative advantage in PV.30 Genetic variation affecting expression of the ACOT family may provide protection against PV in some individuals with the JAK2 46/1 haplotype. The gene discussed is JAK2; the disease is acquired polycythemia vera.