Our results are consistent with the premise that senescent cells, particularly senescent monocytes, may either contribute to or be driven by declines in diverse age-related and obesity-related clinical outcomes, including loss of mobility, increased body fat (BMI, fat percentage, waist size), increased blood pressure, elevated triglycerides and lipids, elevated glucose and A1C, and inflammation (CRP and IL6). Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.