Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a senescence-associated protein that, when targeted with a senolytic vaccine, results in the reduction of senescence burden and improvements in aging and obesity-related outcomes in mice, including improved glucose homeostasis on high fat diet, and reduced aortic plaque size in APOE KO mice63. Here, APOE is linked to obesity due to melanocortin 4 receptor deficiency.