XBP1 and melanoma: It reduces the growth of melanoma cells (A375 and B16F10) in vitro in a dose-dependent manner, induces ER stress via the inositol-requiring enzyme type 1 (IRE1)/X-box binding protein 1 (Xbp1) pathway, and prompts caspase-12/caspase-4-mediated death in both cell lines.