AKT1 and melanoma: Sasanquasaponin III is a triterpenoid saponin obtained from Schima crenata Korth that induces autophagy in melanoma A375 cells by Akt/mTOR/p70 ribosomal S6 kinase (p70S6K) pathway inhibition, ROS accumulation, and LC3-II expression upregulation.61