Thus, the resemblance of parts of MFG-E8 with coagulation factors probably explains its anticoagulant properties, as it may act as competitive inhibitor for binding of these coagulation factors to membranes.14 The role of MFGE-8 in phagocytosis15 may also be relevant in the context of dementia.16,17 The focus of this review, however, will be geared towards the role of medin in the vascular contribution to dementia. Here, MFGE8 is linked to dementia.