These results were confirmed in the Tg2576 murine model of AD, which overproduces and accumulates Aβ, by the demonstration that biologically relevant concentrations of Aβ1‐42 elicit α7 nAChR‐dependent elevations in the level of calcium in hippocampal CA1 astrocytes and induce NMDA receptor‐mediated slow inward currents in CA1 neurons [100]. Here, CHRNA7 is linked to Alzheimer disease.