MAPT and Alzheimer disease: Interestingly, evidence suggests that cotinine ([5S]‐1‐methyl‐5‐[3‐pyridyl]‐pyrrolidin‐2‐one), the main metabolite of nicotine, has similar beneficial properties against AD pathology as nicotine to improve memory, prevent memory loss, and lower Aβ burden in AD, as well as reduce cortical tau phosphorylation.