The phenomenon of CIMP, characterized by widespread hypermethylation of CpG islands, is associated with distinct clinical and pathological features of CRC, including MSI and BRAF mutations.172 Clinical studies confirmed that none of the tumors of MMR germline mutations cases showed positive for BRAFV^600E, suggesting that BRAF^V600E mutation-specific immunostaining has a low risk of excluding Lynch syndrome patients. This evidence concerns the gene BRAF and Lynch syndrome.