Furthermore, the Hippo pathway has emerged as a critical player in the context of oncogenesis, credited with tumor-suppressive functions that are mediated through various components like the fat storage-inducing transmembrane protein, the serine/threonine-protein kinases LATS1/2, the MST1/2 kinases, the transcriptional co-activators TAZ and YAP1, and the TEAD family of transcription factors72 (Fig. 2). The gene discussed is AKT1; the disease is neoplasm.