For instance, mutations in the AXIN2 gene, which plays a role in the WNT signaling pathway, have been identified in families with dominantly inherited tooth agenesis and CRC.122 Based on this, AlkB homolog 5 (ALKBH5), an RNA N6-methyladenosine eraser was found to be the target of Axin, and could be combined with programmed cell death protein 1 (PD-1) treatment after being coated with vesicle to slow down CRC progression.123. This evidence concerns the gene PDCD1 and colorectal carcinoma.