ATAT1 and malignant colon neoplasm: CRISPR-mediated knockout of PC substantiated its role in promoting tumorigenesis, offering a new target for therapeutic intervention.493 Oh et al. demonstrated that αTAT1, a tubulin acetyltransferase, modulates Wnt1 expression, thereby influencing microtubule acetylation and the malignant properties of colon cancer cells.