SAA2 and colorectal carcinoma: Proteomics has become a fundamental tool in the discovery of novel candidate protein biomarkers that are potentially secreted into bodily fluids such as blood, urine, and saliva.416 In a notable study, Ahn et al. utilized a CNN classification approach to identify a panel of five proteins—SAA2, APCS, APOA4, F2, and AMBP—that are indicative of both early and advanced-stage CRC.417 Additionally, the role of PTMs in proteomics has been emphasized in relation to their critical contributions to early diagnosis, prognostic stratification, and therapeutic approaches in CRC.