SLC25A22 and colorectal carcinoma: Disruption of this pathway through SLC25A22 knockdown results in DNA demethylation and reactivation of protocadherins, subsequently inhibiting WNT/β-catenin signaling, diminishing stem cell traits, and reducing resistance to 5-FU.461 Although primarily investigated in cell lines, human tissue samples, and animal models, this pathway bears considerable promise for not only CRC treatment but potentially other malignancies as well.