This interaction presents a viable therapeutic target in CRC.424 Additionally, the spatial localization of immunological markers within tumors could serve as predictive indicators of colon cancer metastasis.425 In a comprehensive study involving scRNA-seq and spatial transcriptomics on 97 matched samples, Wu et al. identified metabolically active MRC1 + CCL18 + M2-like macrophages predominantly in metastatic tumors and their peripheries. The gene discussed is MRC1; the disease is colorectal carcinoma.