PHRF1 and colorectal carcinoma: Ganetespib represents a promising approach to modulating DNA methylation and reactivating silenced genes in CRC.465 The depletion of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) in conjunction with histone deacetylase (HDAC) inhibition has been shown to trigger rapid DNA demethylation, reactivating silenced genes and significantly reducing CRC cell proliferation.