HER3, characterized by its impaired kinase activity within the receptor tyrosine kinase family, necessitates dimerization with another ErbB receptor to achieve phosphorylation, typically with the oncogenic HER2.54 The HER2/HER3 axis, often co-expressed in tumors, is believed to play a substantial role in CRC cell growth. Here, ERBB3 is linked to colorectal carcinoma.