SDC2 and colorectal carcinoma: Specific biomarkers such as SFMBT2, ITGA4, THBD, and ZNF304 have emerged as critical indicators for early CRC screening at the tissue level, while methylation patterns of genes like KCNJ12, VAV3-AS1, and EVC are being employed to stage CRC accurately.410 Additionally, methylation anomalies in SEPT9 and SDC2 detected in fecal samples are proving to be effective for non-invasive early detection of CRC.411 The therapeutic landscape is also evolving with the proposal to use DNA methyltransferase inhibitors to target methylation abnormalities in CRC treatment strategies.