Thus, PCDHB3’s expression and cellular localization are considered valuable prognostic indicators for advanced CRC.474 Methylation of retinoic acid induced 2 has been identified as an independent marker of poor prognosis in CRC, obstructing the protein kinase B (AKT) signaling pathway and curtailing CRC cell proliferation both in vitro and in vivo. The gene discussed is RAI2; the disease is colorectal carcinoma.