Proteomics has become a fundamental tool in the discovery of novel candidate protein biomarkers that are potentially secreted into bodily fluids such as blood, urine, and saliva.416 In a notable study, Ahn et al. utilized a CNN classification approach to identify a panel of five proteins—SAA2, APCS, APOA4, F2, and AMBP—that are indicative of both early and advanced-stage CRC.417 Additionally, the role of PTMs in proteomics has been emphasized in relation to their critical contributions to early diagnosis, prognostic stratification, and therapeutic approaches in CRC. This evidence concerns the gene APOA4 and colorectal carcinoma.