DIRAS1 and colorectal carcinoma: There is also frequent hypermethylation of DIRAS1 in CRC, governed by its promoter methylation, suggesting its potential as a marker for poor prognosis.475 The lysine methyltransferase, suppressor of variegation 3–9 homolog 2, has been implicated in CRC prognosis and is known to promote malignant traits by tri-methylating the slit guidance ligand 1 promoter.