MAPK8 and colonic neoplasm: For instance, JNK activation can lead to the nuclear translocation of Yki, a component of the Hippo pathway, thereby promoting cell proliferation.92 JNK has also been implicated in the activation of YAP1 in response to DNA damage and may facilitate the inhibition of Hippo pathway kinases through interactions with molecules like Ajuba.93 While the connections between JNK and the Hippo pathway in mammalian colon cancer remain to be fully elucidated, their interplay in CRC tumorigenesis is a subject of ongoing research.