TP53 and colorectal carcinoma: For instance, miR-135 and miR-155 have been shown to target APC, a negative regulator of the Wnt signaling pathway, which is frequently mutated in CRC.193 Additionally, miRNAs such as let-7 and miR-143 target the oncogene KRAS, influencing the MAPK/ERK signaling cascade and thereby impacting cell proliferation and survival.194 The tumor suppressor gene TP53 is also regulated by several miRNAs, including miR-125b, which modulates the p53-dependent apoptotic pathway.195