YAP1 and colorectal carcinoma: For instance, the Hippo pathway effector YAP is transcriptionally regulated by the β-catenin/TCF4 complex in CRC cells, highlighting a synergistic interaction that can influence cellular growth and apoptosis.37 Moreover, an intricate relationship exists between the Notch and Wnt pathways, as evidenced by the ability of Notch to modulate Wnt signaling, a finding initially observed in Drosophila models.