DNMT1 and colorectal carcinoma: Overexpression of DMTN has demonstrated potential in curbing the invasion and metastasis of CRC cells, suggesting its utility as a therapeutic target in precision medicine strategies for CRC patients.464 The heat shock protein 90 (HSP90) inhibitor, ganetespib, has proven effective in affecting DNA methylation by downregulating DNMT expression, which correlates with global DNA methylation levels in CRC cell lines.