Emerging evidence illustrates the ability of PI3K/Akt to modulate the Hippo pathway, promoting the phosphorylation of YAP to foster colon cancer cell proliferation.47 Additionally, the activation of the mechanistic target of rapamycin (mTOR) by PI3K/Akt propels protein synthesis, influencing cell metabolism and growth. The gene discussed is PIK3CA; the disease is colonic neoplasm.