NFKB1 and plasma cell myeloma: Taken together, our analyses reveal that NF-κB dynamics in myeloma cells is different compared to both HS-5 and other previously reported cell types [18, 37, 38] The high basal levels in MM.1S cells are suggestive of autocrine/paracrine NF-κB modulation [9] at population level [39], possibly determined by a minority of highly activated cells that might signal to the rest of the population (Supplementary Fig. 7).