We previously showed that the absence of Them2 expression in skeletal muscle altered expression of secreted myokines, including interleukin-15, chemokine ligand 1, and musclin, suggesting a potential mechanism whereby skeletal muscle Them2 ablation may have limited the development of hepatic steatosis in response to HFD feeding (12). The gene discussed is ACOT13; the disease is Hepatic steatosis.