Deletion of PC-TP in skeletal muscles abrogated the WT Them2-induced increase in hepatic steatosis, as assessed by histopathology (Fig. S3C) and hepatic concentrations of triglycerides (Fig. S3D), total cholesterol (Fig. S3E), free cholesterol (Fig. S3F), and free fatty acids (Fig. S3G). Here, ACOT13 is linked to fatty liver disease.