A diverse set of insights from research from this region identified well established associations, such as the one between the APOE ε4 allele and Alzheimer’s disease, and novel insights including previously unidentified genetic variations from India that are involved in amyloid signalling.118 Variations and mutations in APOE,119-122PGRN, MAPT,123,124 and others were associated with disease risk, with strong association between APOE ε4 allele and Alzheimer’s disease and vascular dementia. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.