Additionally, it enhances T-cell activation, proliferation, neutrophil mobility, adherence, and chemotaxis.6 Furthermore, levamisole acts as a hapten, promoting the production of antibodies against granulocyte antigens, which triggers an immune response resulting in leukocyte destruction.8,10 Another hypothesis suggests that levamisole may serve as a substrate for myeloperoxidase, forming reactive metabolites that could stimulate autoimmunity.7 This evidence concerns the gene MPO and Autoimmunity.