Here, using alectinib‐induced DTP cells generated from two different ALK+ NSCLC cells, we demonstrated that although both DTP cells contained high amounts of ROS due to the downregulation of antioxidant genes by ALK signal inhibition under alectinib treatment, both DTP cells were able to evade or minimize ROS‐induced cell death including ferroptosis and apoptosis by erasing ROS through increasing GPX4 protein levels. The gene discussed is GPX4; the disease is non-small cell lung carcinoma.