This suggests that GPX4 protein plays an essential role as a regulator of ROS‐induced cell death not only under treatment with ALK‐TKI alone but also under treatment with ALK‐TKI plus various types of bypass pathway inhibitor involving EGFR‐ and FGFR‐TKI in ALK+ NSCLC cells. The gene discussed is ALK; the disease is non-small cell lung carcinoma.