SAMP8 mice show typical pathological features associated with AD, such as age-dependent learning and memory decline, Aβ plaque deposition, tau protein hyperphosphorylation, oxidative stress, glial cell degeneration, neuroinflammatory response, synaptic changes and neuronal degeneration loss during the growth process, which is a commonly used animal model for AD research [20]. The gene discussed is MAPT; the disease is Alzheimer disease.