A total of 54 oncogenes, including four that are known to be mutated in leukemia (NSD2, CCND3, U2AF1, and JAK2)22, showed ASE in 7/12 HeH ALL samples in trisomic chromosomes, suggesting that the expression of a set of well-known leukemia-related genes could also be altered by gene dosage in HeH ALL, although other causes of ASE cannot be excluded. The gene discussed is NSD2; the disease is acute lymphoblastic leukemia.