GPX4 and glioblastoma: Mechanistically, C5aR1 activates the ERK1/2 signaling pathway to transduce signals into the nucleus; then, these signals target METTL3 expression and stabilize the m6A level of GPX4, thereby upregulating GPX4 expression to prevent ferroptosis in GBM cells and ultimately promoting GBM progression (Fig. 8).