Mechanistically, C5aR1 activates the ERK1/2 signaling pathway to transduce signals into the nucleus; then, these signals target METTL3 expression and stabilize the m6A level of GPX4, thereby upregulating GPX4 expression to prevent ferroptosis in GBM cells and ultimately promoting GBM progression (Fig. 8). The gene discussed is MAPK3; the disease is glioblastoma.