Since the mechanisms by which epigenetic modifications affect the expression of specific genes are interconnected, our study not only reveals important epigenetic features of GPX4 inhibition and GBM cell ferroptosis but also suggests that the anti-GBM effects of GPX4 inhibition and ferroptosis can be achieved through intervention with METTL3 and potentially other molecules mediating epigenetic regulation. The gene discussed is METTL3; the disease is glioblastoma.