The three HGC cases with co-expression of CDK4, MDM2 and β-catenin exhibited the following clinical characteristics: a 24-year-old patient with a tumor located in a short bone and with a favorable outcome, a 63-year-old patient with a tumor located in a long bone and with favorable outcome and a 52-year-old patient with a tumor located in a flat bone and with unfavorable outcome (metastasis and death). Here, CDK4 is linked to neoplasm.