The immunoexpression of IMP3 was observed in 21 of 92 (22.82 %) cases, CDK4 in 13 of 94 (13.82 %) cases, MDM2 in 17 of 99 (17.17 %) cases, and β-catenin in 8 of 90 (8.8 %) cases (Fig. 2), with no significance for percentage of positive cells between the analyzed tumor's group (Fig. 3). The gene discussed is CDK4; the disease is neoplasm.