All cardiac cells express Toll-like receptors (TLR) 2–4 and TLR6, with TLR4-bearing cells activated via a TLR4 signal due to oxidative stress and the accumulation of activated complement during myocardial ischemia reperfusion, which triggers the onset and development of an inflammatory response [20]. The gene discussed is TLR6; the disease is myocardial ischemia.