A link between neurodegenerative disorders and defective autophagosome transport [37] or p62/SQSTM1 accumulation [33] as a major pathological feature has been described, as well as a signal crosstalk between autophagy and apoptosis in regulating the pathogenesis of Alzheimer’s disease (AD) [38]. Here, SQSTM1 is linked to early-onset autosomal dominant Alzheimer disease.