SQSTM1 and Alzheimer disease: Given our evidence that APache depletion interferes with autophagosome trafficking and autophagic clearance of p62/SQSTM1 and initiates apoptosis signaling, we measured the expression of APache by immunoblotting in autopsy sections of the frontal cerebral cortex from a subset of late-onset sporadic AD patients and age-matched cognitively normally aging elderly subjects as controls [39].