The embryonic ectoderm development gene (EED) codes for a core component of the polycomb-repressive complex 2, which has been linked to neurodevelopmental abnormalities, intellectual disability, and neurodegeneration, and microglial EED has been suggested to play a pivotal role in normal synaptic and cognitive functions (Wang et al., 2022). Here, ENSG00000280371 is linked to Intellectual disability.