Toxocara canis-derived peptides, specifically the synthesized peptide fraction from the excretory–secretory Troponin protein peptide, were able to induce cellular changes and decrease cellular viability in colon carcinoma cell lines (HT-29 and Caco2) in a dose-dependent manner and significantly altered the cellular expression of gene (Mcl-2, APAF1, ZEB1, VEGF, cyclin-D1, and caspase-3) involved in cancer progression [82]. This evidence concerns the gene APAF1 and cancer.