IL15RA and melanoma: Since 85% of advanced-stage melanoma patients have lung metastases, which is the leading cause of their death, a study was conducted to investigate the potential of intranasal administration of N. caninum or engineered N. caninum to secrete human interleukin IL-15/IL-15Rα in the microenvironment, in a syngeneic C57BL6 mouse model of B16-F10 melanoma lung metastases.