CD4 and neoplasm: Additionally, secretion of rhoptry and dense granule effector proteins by the non-replicating T. gondii uracil auxotrophs activated anti-tumor immunity through host responses involving CD8α+ DCs, the IL-12/IFN-γ Th 1 axis, as well as CD4+ and CD8+ T cells and reversed immune suppression in the tumor microenvironment [301].