Acupuncture at SP6 showed significant antidepressant-like effects on ovariectomy OVX-induced depression rats, which can reduce endoplasmic reticulum stress and OS in the amygdala, and reduce the expression of related proteins such as 8-OHDG, BiP, p-JNK, PDI, Ero1-Ia, and Calnexin [174]. The gene discussed is MAPK8; the disease is major depressive disorder.