By generating chemo-resistant AML cell lines, it was showed that DAXL-88 exerts dose-dependent cytotoxicity in various AML models, including FLT3-WT THP-1, FLT3-ITD+ MV4-11, and quizartinib-resistant MV4-11 cells. This evidence concerns the gene FLT3 and acute myeloid leukemia.