Notably, a study by Goyette et al.., using the HER2+ Neu FVB/NJ (MMTV-NeuNDL2-5) and NIC (MMTV-NeuNDL2-5-IRES-Cre) mouse models of breast cancer, demonstrated reduced HER2 and HIF-1α levels in AXL KO mice, especially upon hypoxia [87]. This evidence concerns the gene ERBB2 and breast carcinoma.