RAC1 and cancer: In the context of cancer cell migration and invasion, it has been shown that GAS6-induced AXL activation promotes membrane protrusions, cell motility, actin cytoskeletal remodeling, cell spreading and regulation of lysosome peripheral distribution, mainly by PI3K/AKT, MAPK/ERK, JAK/STAT and Ras-related C3 botulinum toxin substrate 1 (RAC1) activation [73–75].