The upregulated genes identified were TERT and GLYCTK, while the downregulated genes were HSPB7, CLDN1, SPPL2B, and ADCY9. Out of the five genes initially identified at an FDR ≤ 0.2 in the melanoma-only analysis, GLYCTK and HSPB7 reached FDR ≤ 0.05 in the extended analysis [Fig. 4b]. The gene discussed is SPPL2B; the disease is melanoma.