PTPN6 and cancer: Here, the hypomethylation of ptpn6 was associated with increased expression of ptpn6. Notably, in KIRC and TGCT, the increased expression of ptpn6 was associated with its poor prognosis and high immunoinfiltration, accompanied by the promoter hypomethylation, reflecting the close relationship between epigenetic modifications (such as methylation) and gene expression, cancer immune environment and prognosis.