Representative IHC images revealed that ptpn6 was highly expressed in breast cancer, cervical cancer, glioma, testis cancer, liver cancer, stomach cancer, endometrial cancer, ovarian cancer and colorectal cancer tissues compared to their corresponding nontumorous tissue, and that its subcellular localization was in the nucleoplasm and cytoplasm (Fig. 1C). Here, PTPN6 is linked to colorectal cancer.