The functional states of ptpn6 were analyzed at single-cell resolution in 14 cancers, including LUAD, non-small cell lung cancer (NSCLC), renal cell carcinoma (RCC), acute lymphoblastic leukemia (ALL), prostate cancer (PC), retinoblastoma (RB), GBM, uveal melanoma (UVM/UM), colorectal cancer (CRC), OV, etc. The gene discussed is PTPN6; the disease is pachyonychia congenita.