89Zr-PEG-(DFB)1(ACUPA)3, 89Zr-PEG-(DFB)3 (ACUPA)1, and prostate cancer-targeting starPEG nanocarriers (40 kDa, 15 nm) with one or three PSMA-targeting ACUPA ligands were designed and synthesized. The gene discussed is FOLH1; the disease is Familial prostate cancer.