Considering the properties of quercetin and its protective effects on the Nrf2/Keap1 pathway in cells against oxidative stress, apoptosis, and inflammation prompted us to investigate the potential of intraperitoneal injection of quercetin in controlling the consequences of ischemia and reperfusion-induced injuries by affecting the Nrf2/Keap1/HO-1 pathway. The gene discussed is KEAP1; the disease is ischemia.