As a consequence, we interrogated if mAdV3 is generally able to modify host inflammasome responses by individually activating NLRP3 (by nigericin treatment), AIM2 (by poly-dAdT transfection) and PYRIN (by treatment with UCN-01) and NLRC4 (infection with SPI-1 induced Salmonella). Here, NLRC4 is linked to infection.