In glioblastoma, the phosphorylation of HNRNP A1 at Ser199 hampers the function of the IRES trans-acting factor (ITAF) on cyclin D1 and c-myc mRNA, while the methylation of HNRNP A1 Arg218/225 sustains internal ribosome entry site-binding (IRES-binding) and preserves cyclin D1 or c-MYC IRES activity. The gene discussed is MYC; the disease is glioblastoma.