LI et al. showed that the positive feedback regulation formed by AKT and mTORC2 can be inhibited by Torin 1 (another mTOR-targeted inhibitor), thereby inhibiting the expression of AKT and ultimately inhibiting the phosphorylation of AUF1 in liver cancer cells, while AUF1 can promote the membrane localization and phosphorylation of AKT. The gene discussed is AKT1; the disease is liver cancer.