Ev-packaged circTLCD4-RWDD3 is taken up by human lymphatic endothelial cells to promote the transcription of lymphangiogenesis factor Prospero homeobox 1 (PROX1) and promote lymphangiogenesis and lymphatic metastasis in non-small cell lung cancer [57]. The gene discussed is PROX1; the disease is non-small cell lung carcinoma.