HNRNPL and non-small cell lung carcinoma: Furthermore, Akt-mediated phosphorylation of HNRNP L at Ser52 hinders its interaction with HNRNP U on caspase-9 mRNA, thereby modulating the ratio of caspase-9a to caspase-9b splice variants, which inhibits cell apoptosis and promotes NSCLC progression [118, 119].