However, deletion of chromosome 9 results in the loss of one single copy of the HNRNP K gene and plays a carcinogenic role by inhibiting p53-dependent p21 expression and promoting tumor development in patients with hematologic malignancies, which indicates that HNRNP K shows oncogenicity not only in various solid tumor but also in hematologic malignancies such as leukemia [138]. This evidence concerns the gene HNRNPK and hematologic disorder.