Zhang et al. found that the cullin-associated and neddylation dissociated 1 (CAND1), which has an abnormally high expression level in liver cancer cells, can inhibit F-box protein 11 (FBXO11) activated HNRNP A2/B1 ubiquitination, thereby inhibiting the degradation of HNRNP A2/B1. Here, FBXO11 is linked to liver cancer.