Additionally, we screened 151 genes with hyper-5hmC, which are significantly involved in SLE-related processes, and 5hmC-modified <i>BCL2</i>, <i>CD83</i>, <i>ETS1</i> and <i>GZMB</i> as SLE biomarkers. This evidence concerns the gene GZMB and systemic lupus erythematosus.