While the lack of significant associations with post-OGTT variables in women with PCOS may be due to smaller sample size and inadequate power, the result could also stem from women with PCOS displaying impaired glucose uptake and insulin signalling in skeletal muscle due to fibrosis and/or metabolic inflexibility (Hansen et al., 2020; Stepto et al., 2020; McDonnell et al., 2022). Here, INS is linked to polycystic ovary syndrome.