Unfortunately,long-term use of synthetic AChE inhibitors causes side effects suchas heart disorders, severe gastrointestinal and liver disorders, diarrhea,insomnia, fainting, nausea and vomiting, muscle cramps, feeling offatigue, headache and dizziness, and weight loss.18−20 Therefore,it is important to evaluate food constituents as natural, reversible,and moderate AChE inhibitors. The gene discussed is ACHE; the disease is heart disorder.