ACHE and early-onset autosomal dominant Alzheimer disease: The enzyme is responsible for the direct hydrolysisof choline esters using a covalent hydrogen bond from serine to histidine.The excessive AChE activity and hydrolysis of choline esters appearing,for example, in Alzheimer disease (AD) contribute to the reductionof ACh concentration below normal, lead to the accumulation of β-amyloidand aggregation of T protein, and affect the formation of fibrosisand inflammation.13,14 The action of AChE cannot beblocked completely in an irreversible manner.