By enrichment analysis, we found that DEGs screened from RNA-seq and proteome data mostly enriched in biological process, molecular function and pathways primarily related to development and regulation of cardiac muscle contraction, actin and actin filament binding and organization, regulation of actin cytoskeleton, DCM, HCM, manifesting that truncation of titin might affect the biological process and molecular function of these DEGs and led to myocardial injury. The gene discussed is TTN; the disease is familial dilated cardiomyopathy.