The most enriched KEGG pathways of the DEGs were dominated by pathways involved in Dilated cardiomyopathy (DCM), vascular endothelial growth factor (VEGF), Hypertrophic cardiomyopathy (HCM), Thyroid hormone synthesis, serine/threonine kinase AMP-activated protein kinase (AMPK), HIF−1, Cardiac muscle contraction, Renin−angiotensin system, Regulation of actin cytoskeleton, etc. (Fig 6B). Here, MARK2 is linked to familial dilated cardiomyopathy.