In previous study, we reported two probands diagnosed with DCM carrying a novel TTNtv c.13254T>G (p.Tyr4418Ter) on exon 46 of TTN (the transcript was NM_133379.5) and constructed a mouse model with TTNtv Y4370* on exon 45 by CRISPR/Cas9-mediated genome engineering to imitate the newly discovered human TTNtv. The gene discussed is TTN; the disease is familial dilated cardiomyopathy.