The air pollution-driven activationof proinflammatory factors like interleukin-6 and tumor necrosis factorα,6,7 leads, among others, to adipocyte accumulation.42 The subsequent accumulation of ectopic fat isassociated with an increased risk of developing both, clinically manifestcardiovascular and metabolic diseases.9,37. This evidence concerns the gene IL6 and metabolic disease.