NPPB and heart failure: Moreover, in the post-hoc analysis of the ILLUMINATE‐CS (238 patients, median follow-up 3 years), high baseline BNP was described as an independent predictor of the combined end point of all‐cause death, heart failure hospitalization, and fatal ventricular arrhythmia (log‐rank P = 0.004) in patients with CS without heart failure at the time of diagnosis, and these findings were also retained even after adjusting for age, kidney function and baseline LVEF (HR, 2.06 [95% CI, 1.19–3.55]; P = 0.010) [37].