Natural compounds extracted from plants and vegetablescan activate NFE2L2, thus increasing the activityof antioxidant enzymes and mitigating damage resulting from oxidativestress and high blood sugar.41NFE2L2 is a transcription factor that promotes antioxidantactivity by controlling the expression of genes responsible for producingantioxidant enzymes, including glutathione peroxidase (GSH Px), GST,superoxide dismutase (SOD), heme oxygenase-1, and NAD(P)H oxidoreductase-1.20NFE2L2 protects the kidneysagainst diabetic kidney disease by suppressing oxidative stress andinflammation.23 Here, HMOX1 is linked to diabetic kidney disease.