NFE2L2 and cardiovascular disorder: Because miR-709 was identified as one of the top 10 upregulatedgenes identified in our miRNA microarray validation and because NRF2has been described to play a role in cardiovascular disease, we investigatedwhether miR-709 mediates cellular oxidative stress by targeting NFE2L2 in HG + PA (which mimic glucolipotoxicity state)-treatedMES-13 cells.