We found that deletion of OGT (<i>Ogt<sup>-/-</sup></i>) caused a marked reduction in tumor growth in both syngeneic mice tumor models and a genetic mice colorectal cancer (CRC) model induced by mutation of the <i>Apc</i> gene (<i>Apc<sup>min</sup></i>). The gene discussed is APC; the disease is colorectal carcinoma.