Moreover, we observed the presence of GADA (glutamic acid decarboxylase autoantibodies, one of the anti‐islet autoantibodies resulting from β‐cell destruction mediated by T‐cells) in T1DM patients with PLAGL1 overexpression, exhibiting clinical features such as heightened insulin dependence, ineffectiveness of sulfonylureas, and pancreatic β‐cell apoptosis.12, 13, 14. The gene discussed is PLAGL1; the disease is type 1 diabetes mellitus.