APOE and hyperlipoproteinemia type 3: In contrast to APOE ε4-associated dyslipidemia, APOE2 carriers tend to have high triglyceride levels (14,35), and up to 10% of APOE2 homozygotes have familial dysbetalipoproteinemia, an atherogenic disorder characterized by an accumulation of triglyceride-rich lipoprotein remnants (36).