In unadjusted analysis, T2DM incidence was significantly lower in APOE2+ compared with APOE3 carriers (hazard ratio = 0.85 [95% confidence interval (CI): 0.73–0.99], p = .03; Table 2) and did not differ significantly between APOE4+ and APOE3 carriers (0.92 [0.82–1.04], p = .20). The gene discussed is APOE; the disease is type 2 diabetes mellitus.