Accordingly, APOE KO rabbits showed elevated cholesterol and triglyceride (TG) levels on a standard diet [46], while APOC3 KO rabbits demonstrated accelerated catabolism of TG-rich lipoproteins, which resulted in resistance to cholesterol-rich diet-induced hyperlipidaemia and inhibited atherosclerosis [47, 49], and CETP KO rabbits even on cholesterol-rich diet had higher HDL-C levels and lower total cholesterol levels, and reduced levels of both aortic and coronary atherosclerosis compared to wild-type rabbits [48]. The gene discussed is APOE; the disease is atherosclerosis.