During recent years, several zebrafish models for hyperlipidaemia and atherosclerosis have been established, including a simple high-cholesterol diet-induced model and more advanced mutants of lipid metabolism-related genes (such as LDLR [99], APOC2 [100], Liver X receptor (LXR) [101], Apolipoprotein E (ApoEb) [102], and Apolipoprotein A-I binding protein (AIBP) [103]. Here, APOE is linked to hyperlipidemia.