Mechanistically, WWP1 regulates the degradation, the sub‐cellular localization and the activity of protein substrates displaying tumor suppressive functions, such as PTEN, p27Kip1, LATS1 and p53 [3, 14, 15, 16], that are of pivotal importance in cancer [17, 18, 19, 20, 21]. This evidence concerns the gene WWP1 and cancer.